What is Hypericin Powder?
Hypericin Powder is a special botanical compound derived from the flowering aerial parts of Hypericum perforatum L. (St. John's Wort). This powder is prepared in a controlled process of extraction, concentration, and purification, which results in a standardized product that contains a uniform amount and uniformity from batch to batch for industrial applications. It is a naturally derived plant extract, extensively used by manufacturers and formulators in need of a standardized raw material that has well-defined phytochemical properties. The standardised composition, assured botanical origin, and formulation system compatibility are important to value it. The ingredient can be provided in various hypericin levels and specifications to meet customer needs, which can be utilized for dietary supplements, botanical research, functional ingredients, and specialty formulation applications. Advanced manufacturing processes such as the control of solvents, product purification, drying, and quality assurance testing help to guarantee the stability, purity, and adherence to relevant industry standards. The powder has good dispersibility and is versatile for capsules, tablets, sachets, powder blends, botanical premixes, and other value-added formulations.

COA
| Item | Specification | Result | Test Method |
| Product Name | Hypericin Powder | Conforms | Visual |
| Botanical Source | Hypericum perforatum L. | Conforms | Botanical ID |
| Plant Part Used | Flowering aerial parts | Conforms | Supplier Data |
| Appearance | Dark red to reddish-brown fine powder | Conforms | Visual |
| Odor | Characteristic botanical odor | Conforms | Organoleptic |
| Solubility | Slightly soluble in ethanol, insoluble in water | Conforms | Qualitative |
| Manufacturing Method | Solvent extraction, purification, drying | Conforms | Process Record |
| Storage Condition | Cool, dry, away from light and moisture | Conforms | Standard Storage |
| Shelf Life | 24 months | Conforms | Stability Data |
| Hypericin Content | 0.30% | Conforms | HPLC |
| Total Related Compounds | ≥ 1.0% | Conforms | HPLC |
| Loss on Drying | ≤ 5.0% | Conforms | USP |
| Ash Content | ≤ 5.0% | Conforms | Gravimetric |
| Particle Size | 100 mesh (customizable) | Conforms | Sieve Analysis |
| Total Heavy Metals | ≤ 10 ppm | Conforms | ICP-MS |
| Lead (Pb) | ≤ 2.0 ppm | Conforms | ICP-MS |
| Arsenic (As) | ≤ 1.0 ppm | Conforms | ICP-MS |
| Cadmium (Cd) | ≤ 1.0 ppm | Conforms | ICP-MS |
| Mercury (Hg) | ≤ 0.1 ppm | Conforms | ICP-MS |
| Residual Solvents | Complies with ICH Q3C | Conforms | GC-MS |
| Total Plate Count | ≤ 10,000 CFU/g | Conforms | USP |
| Yeast & Mold | ≤ 1,000 CFU/g | Conforms | USP |
| E. coli | Negative | Conforms | USP |
| Salmonella | Negative | Conforms | USP |
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Source
St. John's Wort Extract is derived from a perennial flowering plant, Hypericum perforatum L., or St. John's Wort. It is a native species of Europe, Western Asia, and North Africa, and is now widely grown and naturalised throughout the temperate world thanks to its adaptability and consistent yield of biomass. The main raw materials used for harvesting are flowering tops, blossoms, leaves, and aerial parts at the time of optimal flowering when the natural phytochemicals are in desired concentrations. The harvested plant material is carefully cleaned, dried, and then submitted to a controlled extraction and purification process to isolate specific marker compounds such as hypericin. This extract is then processed, refined, and spray dried or otherwise processed into a stable powder suitable for industrial applications. The chemical composition of botanical products may differ depending on the cultivation area, climatic conditions, harvesting date, and manufacturing process, so a good manufacturer should have a standard sourcing procedure, identity authentication, and quality control standards to guarantee uniformity in the content, traceability, and batch-to-batch consistency for commercial use.
History
It has a long history of use and study, which is closely related to the history of Hypericum perforatum L., St. John's Wort. It has apparently been known to Europeans for centuries in many parts of Europe, and was used as a unique species of botany and regarded as a distinctive species, used in traditional botanical collections, early herbals literature, and in early agriculture. In the late seventeenth and early eighteenth centuries, the new classification of plants and the chemistry of plants raised the scientific interest in the plant constituents of Hypericum perforatum. In the early 1900's, researchers were able to isolate and identify hypericin, the red pigment that naturally occurs in the flowering parts of the plant. Manufacturers were able to produce more constant and pure hypericin extracts in the twentieth century as new extraction technologies were developed, new analytical methods were created, and quality control systems were improved. These technological advancements culminated in the invention, which is now available as a commercial botanical ingredient for use in today's ingredient supply chains, research projects, and standardized formulation projects. Today, Hypericum Perforatum Extract is the result of Inter-Generational Knowledge combined with modern extraction science and a carefully developed production process that is supported by advanced cultivation, processing, and quality assurance methods, which are all compliant with international industry standards.

Precautions
1. Confirm Raw Material Specifications
Prior to production, check the hypericin content, particle size, moisture content, and quality parameters to guarantee that the ingredient will be able to be incorporated into the formulation and procurement requirements.
2. Perform Incoming Quality Checks
Manufacturers should identify and verify the quality of the product on receipt, including when a COA is supplied, to ensure the internal quality and consistency of the batch.
3. Evaluate Formulation Compatibility
It is recommended that you do pilot testing to determine the effect of Hypericin Extract when combined with the other ingredients, carrier, and processing system you will be using in the final product.
4. Control Processing and Storage Conditions
In manufacturing, storage, and transportation, ensure that the product is not exposed to unnecessary excessive heat, moisture, and direct light to maintain the quality of the product. Keep in sealed containers, in a cool and dry area.
5. Conduct Stability and Packaging Assessments
It is advisable to assess the stability of the finished product in the intended storage conditions. The packaging materials used should be suitable for the intended use and application and have a protective function for the botanical ingredient during its entire shelf life.
6. Ensure Regulatory Compliance
Prior to commercializing finished products in various markets, check regional regulatory requirements, labelling regulations, and documentation requirements for smooth entry into markets and managing the supply chain.
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