What is Berberine Hydrochloride Powder?
Berberine Hydrochloride Powder is a high-purity plant-based alkaloid, in dried form (a salt of hydrochloric acid, used in pharmaceutical, vitamin, and livestock with its bioactive properties well-documented and much-used in nutraceutical, pharmaceutical, veterinary, and functional food industries. It is a fine yellow crystalline powder, which is usually extracted and standardized to have the same potency and quality since most of the sources are natural, like Berberis species. Its hydrochloride compound has better stability, solubility, and ease of formulation properties, hence it is applicable in a broad spectrum of industries. It can be supplied in large quantities in the industry to be used in the production of dietary supplements, herbal preparations, feed supplements, and product lines oriented to health. It has found use in the support of metabolic balance, gut health, and microbial control, making it a relevant alternative in evidence-based, regulatory-compliant products developed by companies. It is a highly demanded product in the market, it has a good sourcing potential and compatibility with capsules, tablets, beverages, and usable functional powders, which can guarantee the formulation flexibility and commercial scalability in the mind of a manufacturer.
COA
| Item | Specification | Test Result | Method |
| Appearance | Yellow powder | Conforms | Visual |
| Assay (HPLC) | ≥97% | 97.50% | HPLC |
| Solubility | Soluble in water | Conforms | Visual |
| Loss on Drying | ≤1.5% | 1.20% | 105°C, 2h |
| Residue on Ignition | ≤0.5% | 0.30% | AOAC 921.03 |
| Heavy Metals (As Pb) | ≤10 ppm | 5 ppm | ICP-MS |
| Arsenic (As) | ≤2 ppm | 1 ppm | ICP-MS |
| Microbial Count | Total Plate Count ≤1000 CFU/g | 450 CFU/g | USP <61> |
| Yeast & Mold | ≤100 CFU/g | 20 CFU/g | USP <61> |
| E. coli | Negative | Negative | USP <62> |
| Salmonella | Negative | Negative | USP <62> |
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Working Principle
The most prominent effect on the cell signaling pathway involves the stimulation of amplified-activated protein kinase (AMPK), popularly known as the metabolic switch of the body. Berberine Hydrochloride activates the AMPK signaling pathways, amongst which it has been shown to exert some influence to inhibit fat metabolism and activate muscle-wasting related pathways. This activation is important in regulating energy production, glucose metabolism, as well as lipid metabolism at the cellular level, contributing towards balanced metabolic processes. Moreover, it may affect the composition of the gut microbiota, increase nutrient metabolism efficiency, and balance the enzyme activities of carbohydrates and lipid degradation. The combined effects also transform it into a worthy functional ingredient in sectors that specialize in metabolic health, gut health, and general physiological wellness, with manufacturers now having an evidence-based and multifunctional compound to base their product development on.
Process
1. Raw Material Selection and Preparation
The raw materials are dried, then, using mechanical grinding, the dry materials are finely powdered in order to maximize the surface area during the extraction process of the active alkaloid.
3. Water or Ethanol Extraction
Hot water or aqueous ethanol extraction of the powdered plant stuff is a method that has become widely spread because the yield is maximized and, at the same time, assures industrial efficiency.
4. Filtration and Concentration
The extract is clarified to get rid of solids of the plant, after which it is concentrated under lowered pressure to achieve a rich and dense solution.
5. Acid Conversion to Hydrochloride
To increase the stability, solubility, and bioavailability of the extracted concentrated extract, it is treated with hydrochloric acid to convert the natural berberine to its salt form.
6. Purification
To attain the right degree of purity that is commercial, the crude berberine hydrochloride is subsequently processed into a crystalline form or on a resin adsorbent.
7. Drying
These crystals are dried in controlled conditions of temperature and humidity to avoid the degradation of the products and maximize the quality of the products.
8. Milling and Sieving
The crystals are dried and milled into consistent fine powder and sieved to fulfill their various formulations' particle size needs.
9. Quality Control and Packaging
A final Berberine HCL Powder is strongly tested regarding purity, moisture, and microbial concentrations and packed in bulk containers applicable in industrial distribution.
Suitable For
The main target of the Berberine HCL Bulk will be the companies creating products working with adults who are interested in maintaining metabolic health, lowering any disruptive digestive imbalances, and managing overall physiological health. It is extensively applied in preparations aimed at benefiting people who need help with blood sugar level regulation, sound lipid patterns, and reasonable intestinal microflora. It is used in dietary supplements, functional foods, and veterinary health products in the sector, where it provides manufacturers with a multifunctional but science-backed active component with lifestyle-related metabolic concerns in mind.
Certifications
American warehouse
Exhibitions
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