Name: China Radix Notoginseng Extract Manufacturers, Suppliers, Factory - Wholesale Price - Kingsci
Brand: Kingsci
SKU: 244865074

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Kingsci Biotechnology Co., Ltd.: Your Professional Radix Notoginseng Extract Manufacturer!

Kingsci Biotechnology Co., Ltd. is a manufacturer that has been focusing on natural ingredients for 15 years. It has been engaged in plant separation and purification for a long time and has rich experience in the production of plant extracts. At the same time, Jins Biotechnology Co., Ltd. conducts random inspections, irregular external inspections, and regular type inspections on each batch of products to fully ensure the quality and safety of plant-derived products.

Strong Production Capability

Our factory has more than 3,000 square meters of professional GMP clean workshops and standardized laboratories. We have established a professional R&D team and established a dedicated R&D center.

Leading Service

Our services are refined and standardized. From pre-sales technical consultation to after-sales maintenance, we always put customer needs first and continuously innovate our service value system.

Quality Assurance

With ISO9001, ISO22000, HACCP, KOSHER certifications, we implement comprehensive quality control on each product from raw materials, manufacturing process to final product.

Broad Market

After years of development, our sales network has spread all over the world. We have sales warehouses in New York and Chino, USA.

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What is Radix Notoginseng Extract

Radix notoginseng extract is prepared from the species of the genus panax. Panax notoginseng extract powder contains high potency notoginsenoside, ginsenoside Rb1, ginsenoside Rg1, ginsenoside Rd, ginsenoside Re, and ginsenoside Rb2, which are active ingredients impacting the overall health and nutritionally supporting healthy heart function, blood circulation, and performance.

Benefits of Radix Notoginseng Extract

Activating Blood Circulation, Stopping Bleeding, and Replenishing Blood
Notoginseng saponins can dilate blood vessels, improve blood circulation, reduce blood viscosity, and have the effect of activating blood circulation. Notoginseng alkaloids, the active ingredient of Notoginseng, can promote platelet aggregation and deformation, release substances such as ADP and platelet factor III, and can significantly shorten bleeding and coagulation time, achieving a good hemostatic effect. Notoginseng can promote the division and growth of various blood cells, promote the proliferation and release of bone marrow cells, increase the number and activity of bone marrow red blood cells, improve hematopoietic function, and play a role in replenishing blood.

Protecting the Cardiovascular System
Notoginseng saponins help prevent and treat arrhythmias, myocardial ischemia, myocardial infarction, etc. Total flavonoids can also significantly reduce myocardial oxygen consumption, improve myocardial oxygen metabolism, and inhibit myocardial lipid peroxidation; Notoginseng saponins have a protective effect on heart function during the compensatory period of hemorrhagic shock. Notoginseng also has a protective effect on brain cells after acute cerebral ischemia and hypoxia, and can maintain the stability of the nerve cell membrane and vascular membrane of ischemic brain tissue, and resist the increase in blood pressure and coronary artery contraction caused by the increase in kinase produced by the pituitary gland. Panax notoginseng has a very significant effect on the prevention and treatment of cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, myocardial ischemia, arrhythmia, cerebral thrombosis, cerebral hemorrhage, etc., and is known as the "vascular scavenger".

Anti-Tumor
Panax notoginseng contains Panax notoginseng saponin Rh1 and anti-cancer polyacetylene, which can inhibit the growth of cancer cells. Panax notoginseng polysaccharide can stimulate the phagocytic function of macrophages and inhibit tumor growth.

Protect Liver Function
Panax notoginseng saponin can prevent liver fibrosis and microvascular lesions caused by liver ischemia, protect the liver from damage by chemicals (such as alcohol), and promote liver cell growth.

Calm the Nervous System
Panax notoginseng glycol glycoside can inhibit the central nervous system, calm the nerves, improve sleep, and treat dizziness and tinnitus. Panax notoginseng glycol glycoside also has anti-inflammatory and analgesic effects.

Bidirectional Regulation of Blood Sugar
Ginsenoside Rg1 contained in Panax notoginseng can help regulate blood sugar. The effect of Rg1 on blood sugar depends on the body state and the body's blood sugar level. It can both increase and decrease blood sugar, and has a bidirectional balancing regulation effect.

Improve Immune Function
Panax notoginseng polysaccharide can promote macrophage function, total saponin can increase the total number of white blood cells and lymphocyte ratio in the blood, and can also increase the production of humoral antibodies to a certain extent, which has the effect of improving immunity.

Anti-Aging
Panax notoginseng saponin (PNS) can help remove superoxide anion free radicals (O2); Panax notoginseng saponin Rb1 and others have anti-lipid peroxidation effects, inhibit the formation of lipid peroxidation, and reduce the formation of lipid peroxidation by enhancing SOD activity. Therefore, Panax notoginseng helps to delay aging.

How Does Radix Notoginseng Extract Work

Panax notoginseng contains more than 200 components, including saponins, flavonoids, cyclopeptides, sterols, and polyacetylenes. However, the main bioactive compounds used to assess the quality of Panax notoginseng are ginsenosides Rg1, Rb1, and R1. Ginsenoside Rg1 is mainly found in the roots and rhizomes, while Rb1 can also be found in other parts of the plant. Importantly, the composition of Panax notoginseng varies depending on factors such as the region where it is grown, when it was grown, when it was harvested, and the processing method.

Chemical Composition of Radix Notoginseng Extract

The main components of Panax notoginseng are dammarane-type ginsenosides. Dammarane-type ginsenosides include 20(S)-protopanaxadiol (ppd) and 20(S)-protopanaxatriol (ppt). Panax notoginseng has high content of Rb1, Rd (ppd) and Rg1 (ppt) saponins. A study found that the content of Rb1, Rd and Rg1 in Panax notoginseng was higher than that in ginseng and American ginseng.

Certifications

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Frequently Asked Questions

Q: What are the main benefits of Panax notoginseng?

A: Interestingly, although Panax notoginseng has been traditionally used for its hemostatic properties (ability to stop bleeding), no randomized trials have been conducted in humans to demonstrate this benefit. Panax notoginseng appears to have some cardiovascular benefits. In a meta-analysis, patients with unstable angina pectoris (UAP) treated with standardized oral or injectable Panax notoginseng preparations and traditional medications had lower rates of heart disease and reduced angina symptoms and frequency compared with a control group. However, there was no reduction in the risk of cardiac death.

Q: What are the main disadvantages of Panax notoginseng?

A: Currently, there is limited clinical (human) data on the safety of Panax notoginseng. Cases of rash have been observed after intravenous administration of Panax notoginseng. In addition, other studies have reported cases of nausea, vomiting, and dry mouth. In addition, Panax notoginseng is a CYP1A2 inducer, which means it may interact with drugs or other substances metabolized by this enzyme class.

Q: What is Panax notoginseng?

A: Panax notoginseng (Chinese ginseng) is a perennial plant that belongs to the Araliaceae family. It grows primarily in the Wenshan mountainous region of Yunnan Province, China, but it can also be found in Vietnam at altitudes between 1,200 and 2,000 meters (4,000-6,500 feet). The roots (both raw and processed), fruits, flowers, and leaves of Panax notoginseng are still widely used for medicinal purposes in Traditional Chinese Medicine (TCM).

Q: What are the precautions for using Panax notoginseng?

A: Oral: Panax notoginseng is POSSIBLY SAFE for use for up to 6 weeks. It is generally well tolerated. Side effects may include dry mouth, flushing of the skin, insomnia, nausea, and rash.
Rectal: There is not enough reliable information to know if Panax notoginseng is safe or what side effects it may have. Pregnancy and breast-feeding: Panax notoginseng is POSSIBLY UNSAFE when taken by mouth during pregnancy or breast-feeding. A chemical in Panax notoginseng has caused birth defects in animals. Avoid use.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Panax notoginseng may work like estrogen. Do not use Panax notoginseng if you have any condition that could be aggravated by exposure to estrogen.

Q: What does Panax notoginseng interact with?

A: Aspirin interacts with Panax notoginseng
Taking Panax notoginseng with aspirin may increase the amount of aspirin and Panax notoginseng in your blood. This may increase the side effects of aspirin and Panax notoginseng.
Caffeine interacts with Panax notoginseng
Caffeine is converted and broken down in the liver. Panax notoginseng may increase how quickly the liver breaks down caffeine. Taking Panax notoginseng with caffeine may decrease the effects of caffeine.
Drugs converted by the liver (cytochrome P450 1A2 (CYP1A2) substrates) interact with Panax notoginseng
Some drugs are converted and broken down in the liver. Panax notoginseng may change how quickly the liver breaks down these drugs. This may change the effects and side effects of these drugs.
Warfarin (Coumadin) interacts with Panax notoginseng
Warfarin is used to slow blood clotting. Panax notoginseng may increase the effects of warfarin. Taking Panax notoginseng with warfarin may increase the likelihood of bruising and bleeding. Be sure to check your blood regularly. The dose of warfarin may need to be changed.

Q: How to take Panax notoginseng?

A: Adults most commonly take Panax notoginseng in doses of 100-400 mg, taken orally 1-3 times daily for up to 6 weeks. Consult your healthcare provider for the best dose for your specific condition.

Q: How to take Panax notoginseng?

A: At home, Panax notoginseng can be used to soak in water and drink to promote the healing of minor injuries. Adults use 2 coins (8 grams) of Panax notoginseng and boil it with water, and children use 1-1.5 coins (4-6 grams).

Q: What is the difference between ginseng and Panax notoginseng?

A: Chemical comparison shows that ginseng contains more polysaccharides and amino acids, while Panax notoginseng contains more saponins, volatile oils and polyacetylenes.

Q: What should be avoided when taking Panax notoginseng?

A: When using Chinese medicine to treat any disease, it is recommended to avoid raw, cold, greasy, fish with strong odor, spicy, grilled, baked and fried greasy foods. During this period, it is strongly recommended to choose a light mixed meal.

Q: What are the active ingredients in Panax notoginseng?

A: Panax notoginseng leaves are recognized as a rich source of dammarane triterpenoid saponins, flavonoids, polysaccharides, polypeptides, polyacetylenes and fatty acids. Among them, the saponins as the main active ingredients are mainly protopanaxadiol saponins.

Q: What is the difference between ginseng and Panax notoginseng?

A: It is worth noting that Panax notoginseng does not contain tryptophan, while ginseng does. Ginseng has a higher total amino acid content than Panax notoginseng. The differences in the content of various amino acids may be related to different regions, harvesting time, and different parts of the plant.

Q: What are Panax notoginseng used for?

A: Panax notoginseng is a plant that grows in the mountains of southwest China. Its roots are sometimes used as medicine after growing for 3-5 years. Panax notoginseng may dilate blood vessels, improve blood flow, and lower blood pressure.

Q: What is the ethnopharmacology of Panax notoginseng?

A: Panax notoginseng is a traditional Chinese medicine with a warm nature, sweet taste, slightly bitter taste and non-toxicity. Unlike many widely used herbs, Panax notoginseng has always been used in a more concentrated way. Traditional pharmacopoeias list it as one of the most effective herbs for promoting blood circulation and stopping bleeding. Herbal studies have shown that Panax notoginseng originated from the Compendium of Materia Medica, which states: "Panax notoginseng is a medicine for the blood of the Yangming and Jueyin meridians and can treat various blood diseases." Later, the medicine was used to remove blood stasis, stop bleeding, reduce swelling and relieve pain, mainly in surgery and trauma. For example, it was used to remove dead tissue and regenerate new flesh in the Golden Chamber of Medicine King. The Records of Integrated Chinese and Western Medicine used it to treat various bleeding diseases such as hemoptysis, hematemesis, blood in the stool and hematuria. The Supplement to Compendium of Materia Medica used it to treat bleeding caused by trauma. Panax notoginseng is the main ingredient of Yunnan Baiyao, a popular hemostatic Chinese medicine used to treat wounds, stop bleeding, reduce inflammation and relieve pain.

Q: What is the phytochemistry of Panax notoginseng?

A: The roots, stems, leaves and flowers of Panax notoginseng have been studied for phytochemistry. According to a recent summary, more than 200 chemical components have been isolated from Panax notoginseng, including saponins, polysaccharides, notoginseng bases, amino acids, flavonoids, phytosterols, cyclopeptides, sugars, fatty acids, volatile oils, aliphatic acetylenes and trace elements. Saponins are the main components of Panax notoginseng and are considered to be the main active compounds. More than 100 saponins have been isolated and identified, including ginsenosides, notoginseng saponins and gypenosides. The flavonoids isolated from Panax notoginseng are mainly flavonols and flavonoid glycosides, such as glycyrrhizin, quercetin and kaempferol-3-O-α-L-rhamnoside. Only 14 cyclopeptides have been isolated recently, and all of them are cyclodipeptides. The sterols isolated from Panax notoginseng include β-sitosterol, carrot sterol, stigmasterol, stigmasterol-3-O-β-D-glucopyranoside, stigmaster-7-ene-3β-ol-3-O-β-D-glucopyranoside, etc. There are few reports on polyacetylenic compounds in Panax notoginseng. The sugars in Panax notoginseng include monosaccharides, oligosaccharides and polysaccharides, and there are more than 19 amino acids, of which 7 are essential amino acids for the human body. The volatile components of Panax notoginseng include terpenes, alcohols, aldehydes, olefins, alkanes, etc. Terpenes account for a high proportion and are important components. Although there are many active ingredients in Panax notoginseng, current pharmacological research mainly focuses on saponin components.

Q: What are the pharmacological effects of Panax notoginseng?

A: Panax notoginseng is a precious traditional Chinese medicinal material with multiple pharmacological effects. The protective effects of Panax notoginseng on cardiovascular disease and diabetes have been reviewed, and its pharmacological effects include hemostatic and wound healing activities, antioxidant activity, anti-inflammatory activity, hypoglycemic and anti-hyperlipidemic activities, anticoagulant activity, neuroprotective effects, hepatoprotective effects, renoprotective effects, antitumor activities, and estrogen-like activities. Most pharmacological studies have focused on saponins or sterol glycosides, although polysaccharides with immunoenhancing properties, proteins with antifungal, ribonuclease, and xylanase activities, and triglycerides (trilinoleyl) with antioxidant activities have been reported. These may contribute to the mechanism of action of Panax notoginseng in its anti-aging and anti-aging-related diseases.

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