What is L-glutathione Powder?
L-Glutathione Powder is a high-purity bioactive tripeptide consisting of L-glutamic acid, L-cysteine, and glycine that is known to be key in maintaining cellular redox balance and oxidative stability in biological and industrial systems. It is the reduced and physiologically active form, which is widely produced by advanced microbial fermentation using non-GMO yeast strains or by enzymatic synthesis, guaranteeing constant value in quality, high assay value (≥98% by HPLC), and excellent solubility. In commercial production, it is in the form of fine white to off-white crystalline appearance, with good chemical stability and low smell, thus having good compatibility with a wide variety of formulations. It is a functional raw material used in many different industries, such as nutraceuticals, pharmaceuticals, cosmetics, and food technology. In nutraceutical applications, it is used as a biofunctional additive in tablets, capsules, and beverage formulations and has a redox-regulating and stabilizing activity without sensory properties alteration. In the cosmetic field, it is used as a formulation stabilizer, brightening agent enhancer, which plays a role in maintaining the uniformity of the product and its oxidative protection in emulsions, serums, and skin care systems. Within the pharmaceutical and biotechnological world, it is used in formulations at the need of accurate redox modulation and controlled oxidation environments.

COA
| Item | Specification | Result | Test Method |
| Appearance | White or off-white crystalline powder | Conforms | Visual |
| Odor & Taste | Characteristic | Conforms | Organoleptic |
| Assay (Glutathione, total) | ≥ 98.0% | 99.10% | HPLC |
| Loss on Drying | ≤ 0.5% | 0.21% | USP <731> |
| Residue on Ignition | ≤ 0.2% | 0.06% | USP <281> |
| pH (2% Solution) | 2.0 – 3.0 | 240.00% | USP <791> |
| Optical Rotation [α]D20 | -15° to -17° | -16.2° | USP <781S> |
| Heavy Metals | ≤ 10 ppm | <10 ppm | ICP-MS |
| Lead (Pb) | ≤ 2 ppm | <2 ppm | ICP-MS |
| Arsenic (As) | ≤ 1 ppm | <1 ppm | ICP-MS |
| Cadmium (Cd) | ≤ 1 ppm | <1 ppm | ICP-MS |
| Mercury (Hg) | ≤ 0.1 ppm | <0.1 ppm | ICP-MS |
| Total Plate Count | ≤ 1,000 cfu/g | <100 cfu/g | USP <61> |
| Yeast & Mold | ≤ 100 cfu/g | <10 cfu/g | USP <61> |
| E. coli | Negative | Negative | USP <62> |
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Dosage
In industrial and formulation situations, the recommended level of use of Glutathione Powder is typically determined depending on the concentration of the active component, reduced glutathione (GSH), and the form of application. For most nutraceutical and functional food formulations, it is commonly incorporated at levels of between 50 mg and 500 mg per serving, depending on the positioning of the product, desired functionality, and formulation matrix. In the area of cosmetic and personal care products, the level of addition is generally 0.1% - 2.0% of the total weight of the formulation and provides efficient stabilization and oxidative protection, all while maintaining the texture and compatibility of the formulation. For the purposes of pharmaceutical and biotechnological applications, the dosage or concentration is tailored according to formulation design, process conditions, and desired technical outcome. It is important that all manufacturers, contract formulators, and brand owners ensure that the final usage levels are in line with the regulatory standards, safety limits, and labelling requirements of the target market or region, as permissible dosage and purity specifications may be different under different national or regional regulatory frameworks.
Application
1. Nutraceutical and Functional Food Industry
In the nutraceutical sector, it is popular for use in nutritional supplements, fortified beverages, and nutritional blends as a functional ingredient. It plays a role in enabling the redox equilibrium and stability of formulations as well as in developing high-quality wellness formulations. The solubility and compatibility are good with amino acids, vitamins, and botanical extracts, which makes it suitable for powders, capsules, and effervescent tablets.
2. Pharmaceutical and Biotechnology Industry
Within the pharmaceutical manufacturing and laboratory research, it is used as a biochemical reagent and stabilizer excipient in formulations that need accurate oxidation-reduction control. It is used in the formulation development of drugs, biochemical assays, and cell culture systems to provide redox-sensitive environments to make sure of the experiment or production results under controlled conditions.
3. Cosmetic and Personal Care Industry
In cosmetics, it is used in skin-brightening, anti-aging, and protective formulations because of its ability to ensure the integrity of the products and retard oxidative degradation. It is widely used in emulsions, serums, masks, and lotions to increase the stability of active compounds and improve the appearance and preservation of the product.
4. Food Processing and Flavor Stabilization Industry
As an antioxidant and processing aid, it has been used in the food industry to enhance the flavour retention, dough conditioning, and colour preservation properties in a variety of processed foods. It helps to ensure that the products are fresh and appealing while in storage, adding to the consistency of quality and the stability of products on the shelf.
5. Chemical and Bioprocessing Industry
In industrial biotechnology, Glutathione Reduced Powder is used as a Redox mediator and biochemical intermediate in the production of enzymes, optimization of fermentation, and fine chemical synthesis. Its redox modulating ability is useful for catalytic reactions as well as for the protection of sensitive compounds in complex production systems.

Safety
Pure Glutathione Powder has been found to be highly safe and reliable for industrial and formulation applications based on its toxicological evaluation and stringent adherence to international quality standards. It has been subjected to standardized toxicological tests and has shown good safety characteristics under normal conditions of manufacture and formulation, with no signs that irritation or sensitization will occur in normal concentrations of use. Commercial L-Glutathione is prepared in facilities licensed by cGMP (Current Good Manufacturing Practice) and ISO quality management systems, which guarantee purity of the product, traceability, and consistency between batches. Additionally, it is thought to be low allergenic and is made with no GMO raw materials or common allergens, like gluten, soy, and artificial preservatives. Each production lot undergoes thorough analytical tests so as to ensure checks for parameters like heavy metals, residual solvents, and microbiological limits in order to ensure compliance with international regulatory systems for food, cosmetic, and pharmaceutical ingredients. These measures together ensure that it is manufactured to the safety and quality of strict professional standards required for manufacturing in the global environment.
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