What is Bulk L-Ergothioneine Powder?
Bulk L-Ergothioneine Powder is a water-soluble, high-purity antioxidant ingredient popular in blend-filling dietary supplements, cosmetics, functional food, and high-tech skin care products. A naturally occurring amino acid derivative is mainly produced by the fermentation process or is extracted naturally, e.g., by edible mushrooms, and is well-established as having a unique cellular protective ability and exhibiting high stability due to its chemical characteristics in a wide variety of formulation applications. Being a low-toxic and bioavailable compound used in the B2B industry, and becoming increasingly established as an adjuvant in cellular health, mitochondrial health, and oxidative stress replacement in high-performance health and wellness products. It is pH-, heat-stable, and adaptable to most delivery systems, ideal as demand increases in nutraceutical, personal care, and functional beverage sectors, as it can be applied in capsules, sachets, serums, and emulsions. It offers a high-utility, well-studied ingredient solution to companies looking to build premium formulations based on longevity, stress resilience, and skincare wellness without the use of synthetic ingredients.

COA
| Item | Specification | Result | Method |
| Appearance | Off-white powder | Light beige powder | Visual Inspection |
| Assay (Ergothioneine) | ≥ 98.0% | 98.30% | HPLC |
| Identification | Positive | Positive | HPLC & UV Spectrum |
| Loss on Drying | ≤ 1.0% | 0.42% | USP <731> |
| Residue on Ignition | ≤ 0.5% | 0.18% | USP <281> |
| pH (1% Solution) | 5.5–7.5 | 6.1 | USP <791> |
| Heavy Metals | ≤ 10 ppm | < 5 ppm | ICP-MS |
| Lead (Pb) | ≤ 2.0 ppm | 0.32 ppm | ICP-MS |
| Arsenic (As) | ≤ 1.0 ppm | 0.09 ppm | ICP-MS |
| Cadmium (Cd) | ≤ 1.0 ppm | 0.05 ppm | ICP-MS |
| Mercury (Hg) | ≤ 0.1 ppm | Not Detected | ICP-MS |
| Total Plate Count | ≤ 1,000 CFU/g | < 100 CFU/g | USP <61> |
| Yeast & Mold | ≤ 100 CFU/g | < 10 CFU/g | USP <61> |
| E. coli | Negative | Negative | USP <62> |
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Recommended Dosage
The intended levels of use in L-Ergothioneine powder are variable with the end application, but in general applications, the typical levels of use in cosmetics and topical products are in the range of 0.01-0.5 percent, or more and in dietary supplements the common uses are in the range of 5 mg to 30 mg per serving. And when formulators add them to oral products, like capsules, tablets, or even functional drinks, they usually strive to find an effective dose that represents a balance between bioavailability and formulation efficiency. Its potent oxidative benefits also enable low inclusion rates in skin care with visible benefit, and it is thus ideal in serum, cream, and emulsions with specific anti-fatigue or rejuvenating claims. Formulators should carry out compatibility and stability studies on their own matrix so that they give the best performance. The usage, just like any bioactive ingredient, should be according to the regulatory guidelines known in the targeted market.
Application
1. Nutraceuticals:
It is one of the most widely used dietary supplements, which can provide cellular protection and metabolic health support. It can be found in most of its combinations to address stress management, vitality, and healthy aging.
2. Cosmetics and Personal Care:
L-Ergothioneine in skincare is used to develop anti-aging serums, moisturizers, and sun care products. The fact that it contributes to the reduction of oxidative stress also means that people have preferred to use it to protect the skin against environmental damage and enhance their general skin tone and strength.
3. Functional Foods and Beverages:
Products that contain it include wellness drinks, protein powders, and fortified snacks to improve the antioxidant balance of such food products, which target longer-term health and performance.
4. Pharmaceuticals and Medical Nutrition:
There is still little known about it, but it is already a hot topic in the development of specialized formulas (both in the medical nutrition environment and in preventive health) designed to contribute to a healthy mitochondrion and regulation of energy levels in cells.
5. Animal Nutrition:
It can be found in high-value pet food of high value and livestock supplements, where the accepted benefits include oxidative stability and immune support, and particularly in older or performance-oriented blends.

Safety
Amino Acid Ergothioneine is defined as a very safe and tolerated compound with a huge body of toxicological data and regulatory acceptance in various parts of the world. It is an endogenous amino acid derivative that naturally occurs in food and has a long history of human consumption (e.g., mushrooms, beans, and organ meats). Its low toxicity, high stability, and ideal bioavailability have been shown by preclinical and clinical studies, and it is ideal to be used in the long term both orally and topically. It has been recognized as safe when properly used by regulatory agencies, including the European Food Safety Authority (EFSA) and the United States Food and Drug Administration (US FDA), which have authorized its use at consumption levels of zero to no obvious health effects. It is also non-irritating and non-sensitizing in nature, and can be used in sensitive formulations, especially in skincare and nutritional products, which aim at overall protection of the cells and maintenance of oxidative balance.
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