Impact on pathogenic microorganisms
Allicin has a strong antibacterial and anti-inflammatory effect, and has inhibitory or killing effects on a variety of cocci, bacilli, fungi, viruses, etc. Allicin can significantly inhibit or kill a variety of pathogenic bacteria such as Staphylococcus, meningitis, pneumococcus, streptococcus and diphtheria, dysentery, Escherichia coli, typhoid fever, paratyphoid fever, whooping cough, tuberculosis and Vibrio cholerae, etc. Deactivation. It can treat acute bacillary dysentery, whooping cough, infant diarrhea, lobar pneumonia, tuberculosis, wound suppuration, trachoma, etc. The antibacterial principle of allicin is that the oxygen atoms in the allicin molecules combine with the sulfhydryl groups in the cysteine molecules necessary for the growth and reproduction of bacteria to inhibit the growth and reproduction of bacteria.
Allicin can inhibit or kill a variety of pathogenic fungi including Candida albicans. It mainly inhibits the growth of fungi at low concentrations, and can completely kill fungi at high concentrations. It has been clinically used to treat cryptococcal meningitis, fungal infections of the lungs and digestive tract, Candida albicans toxemia, dyspepsia caused by Candida albicans, fungal keratitis, neonatal thrush, tinea capitis, etc. [. The antifungal mechanism of allicin is: inactivation of protein through the oxidation of sulfhydryl groups; competitive inhibition of sulfhydryl-containing compounds such as cystine and glutathione; non-competitive inhibition of the activity of certain enzymes in fungi.
Cytomegalovirus (CMV) infection is one of the main causes of bone marrow transplantation failure and patient death. So far, there are no effective preventive measures. Clinical studies have found that allicin has an obvious preventive effect on bone marrow transplant patients complicated by human cytomegalovirus infection. Cryptosporidium (Crypt0sp0ridium) is a newly discovered pathogen that can cause diarrhea in infants and young children. There is currently no specific medicine for diarrhea caused by Cryptosporidium. The domestic trial use of allicin has achieved good results. Allicin can effectively kill the tachyzoites of Toxoplasma gondii, and has obvious effects on the resistance to toxoplasma infection, especially the recurrence of toxoplasmosis. The dipropenyl dithiol solution of allicin has a destruction rate of 43.5% on the surface antigen of hepatitis B virus, which proves that allicin has a certain destructive effect on the surface antigen of hepatitis B virus. Allicin also has antiprotozoal trichomoniasis effects, and has been clinically proven to have a good therapeutic effect on amoebic dysentery\trichomoniasis vaginitis.
