Steviol glycosides are a kind of natural sweetener with high sweetness and low-calorie value. Its sweetness is 200-300 times that of sucrose, and its calories are only about 1/250 of that of sucrose. Steviol glycosides are a mixture of glycosides extracted from the dried leaves of Stevia rebaudiana, containing Stevioside, Rebaudioside A, Rebaudioside B, Rebaudioside C, Rebaudioside D, Rebaudioside F, Dulcoside A, Rubusoside, Steviobioside.

The pharmacological effects of Stevioside
1. Lower blood pressure and blood sugar
Studies have shown that the principle ofstevioside powder for lowering blood pressure is mainly attributed to three aspects: reducing extracellular Ca²+ influx, reducing Na+ absorption and secondary vasodilator prostaglandin production.
In addition to meeting the sweetness needs of diabetic patients, steviol glycosides also have the role of auxiliary treatment of diabetes: including stimulating the secretion of insulin and the sensitivity of surrounding tissues to insulin, promoting the metabolism of glucose in the blood, and inhibiting the key enzymes of glucose synthesis in the intestine. Reduce blood glucose input.
2. Anti-tumor
Steviol glycosides have a protective effect on epithelial cell shedding and proliferation caused by histamine injury to the gastric mucosa, which may be related to steviol glycosides inhibiting gastric secretion or directly inhibiting pepsin secretion.
3. Protect the intestines
The indigestibility and non-fermentation of steviol glycosides can promote the maintenance of normal intestinal ecology, promote the proliferation of bifidobacteria and lactobacilli in the human body, inhibit pathogenic bacteria such as E. coli, and have a good preventive effect on constipation and rectal diseases. Dilute the human body's toxic substances to prevent the occurrence of cancer diseases.
Application dosage in food
GB 2760-2014 "National Food Safety Standard Food Additives Use Standards" stipulates the use scope and use limit of steviol glycosides (calculated by steviol equivalent). Foods that can be added include tea products, preserved fruits, pastries, flavored fermented milk, Drinks, etc. The maximum allowable addition amount is 10.0g/kg for tea products; the minimum additional amount is 0.2g/kgs, such as flavored fermented milk and beverages. The maximum use amount of steviol glycosides in GB 2760 is based on steviol equivalent, and the conversion relationship is as follows:
Glycoside name | Molecular weight | Equivalent to multiples of steviol equivalent |
Stevioside | 804.38 | 0.395 |
Rebaudioside A | 966.43 | 0.329 |
Rebaudioside B | 804.38 | 0.395 |
Rebaudioside C | 950.44 | 0.334 |
Rebaudioside D | 1128.48 | 0.282 |
Rebaudioside F | 936.42 | 0.340 |
Dulcoside A | 788.38 | 0.400 |
Rubusoside | 642.33 | 0.496 |
Steviobioside | 642.33 | 0.496 |






