Sophora Japonica Extract Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor and interleukin-6 inhibitor. Clinical studies have shown that Luteolin may have pharmacological effects, including antioxidant, anti-inflammatory, antibacterial and anti-cancer.
Luteolin, mostly in the form of glycosides, exists in a variety of plants. These plants contain high content of pepper, wild chrysanthemum, honeysuckle, and perilla, which have antitussive and expectorant effects. Under normal circumstances, respiratory symptoms, cough, sputum, and wheezing, are all related to chronic airway inflammation, such as bronchial asthma, chronic obstructive pulmonary disease, chronic pharyngitis, allergic rhinitis, etc. that causes cough, sputum, and wheezing are all considered It is related to local inflammation and infiltration. The presence of inflammation makes the airway immune response confused, and patients often experience increased airway reactivity. Studies have shown that Sophora Japonica Extract luteolin inhibits the phosphorylation of macrophages and the activity of transcription factor NF-kB and can inhibit the production of cytokines IL-6 and TNF-a by macrophages induced by lipopolysaccharide (LPS). The latter two cytokines play a very important role in the inflammation mechanism and are sensitive indicators that reflect the degree of inflammation. Luteolin can also increase IFN-γ, reduce specific Ig-E, and reduce the infiltration of eosinophils.
In addition to anti-inflammatory and anti-allergic effects, luteolin also has the properties of inhibiting PDE, anti-SARS, and HIV virus. The reason is to inhibit the activity of the SARS virus pre-S protein, thereby preventing it from entering the host cell. It is used to treat chronic cough caused by COPD, bronchial asthma, chronic pharyngitis and allergic rhinitis. In addition, studies have shown that Sophora Japonica Extract Luteolin can inhibit the formation of uric acid and promote the excretion of uric acid.
