Fisetin and quercetin are some of the most prevalent plant flavonoids that are reportedly present in many fruits and vegetables such as apples and onions. Quercetin and fisetin both are flavonols, which are a type of flavonoid naturally found in many plants. And they both are Promising Flavonoids with Chemopreventive. With the increase of incidence of malignant diseases and the prevalence of cancer mortality, fisetin and quercetin, two well-studied flavonoids, experiments have shown remarkable anti-cancer effects in multiple in vitro and in vivo systems.
Fisetin is a flavonoid compound, insoluble in water, carbon tetrachloride and petroleum ether, easily soluble in acetone, acetic acid and other solvents, widely found in strawberries, apples, onions, cucumbers, and other fruits and vegetables, with a wide range of sources. At present, fisetin is generally extracted from Cotinus coggygria in the market in batches, which can effectively save costs through mass production. KS Bio's hot-selling specifications of fisetin 98% and 50% have the following functions in the finished product market,
1. Fisetin has pharmacological properties such as antioxidant, anti-inflammatory and neuroprotective. It can induce tumor cell apoptosis, affect tumor cell signal transduction pathways, inhibit tumor cell proliferation, and inhibit tumor cell migration and invasion. play an anti-tumor effect.
2. Studies have shown that fisetin can also exert an antidepressant effect by inhibiting the monoamine oxidase of the serotonin and norepinephrine systems.
3. It has obvious protective and repairing effects on liver damage caused by hepatitis.
4. Can significantly improve the activity of immune cells.
5. Fisetin can stimulate signaling pathways and improve long-term memory.
Quercetin is one of the more widely studied flavonoids, and its powerful antioxidant and anti-inflammatory activities have been fully proved, with strong biological activities and extensive pharmacological effects. It has anti-oxidative and anti-inflammatory effects that help in many health conditions such as controlling blood sugar, killing cancer cells, preventing heart disease, and many more. In addition, it is also the aglycone of many other flavonoid glycosides. Quercetin combines with rhamnose to form quercetin; rutose to form rutin; arabinose to form guavaside; and lactose to form hypericin.
Quercetin has five hydroxyl groups in the structure, compared to fisetin which has four. Another difference is that fisetin has twice as senolytic potency as quercetin. Both quercetin and fisetin play an important role in healthy aging, as they activate SIRT1, which is an enzyme that plays a vital role in longevity in lower organisms. The effects mimic caloric restriction, which is a proven way to increase lifespan.
