Recently, a new study conducted by the Second University of Naples showed that apple polyphenol extract can increase cholesterol excretion in healthy people by 35%. The study has been published in PharmaNutrition. The study used Italian Annurca apples A new type of nutraceutical formulated with phenol extract (researchers call it AMD).
Through in vitro experiments, the researchers found that apple extract reduced the solubility of cholesterol in micelles by 86%. In a subsequent randomized, double-blind, placebo-controlled crossover study, 50 healthy men and women ate a high-cholesterol diet for 10 consecutive days. Some diets contain apple extract, while others do not. Then there is a 7-day "clean" period, which you can transfer to another group.
According to the results of the study, compared with placebo, apple extract can increase fecal cholesterol excretion by about 35. When evaluating the potential bioactive components of apple extract, the researchers found that NMR data showed that dimeric proanthocyanidins interact with acidic micelles to produce cholesterol through phosphatidylcholine (PC). This indicates that cholesterol can precipitate.
Clinical data shows that when healthy subjects adopt a high-cholesterol diet, AMD may increase fecal cholesterol excretion. Current research shows that AMD is being used as an effective drug to reduce the absorption of cholesterol in healthy subjects. Currently, cholesterol-lowering products on the market usually contain sterols and stantanol in their prescriptions. In many clinical trials conducted in a controlled environment, taking 1.5 to 3 grams of food-derived phytosterol/stannol per day can reduce total cholesterol levels by 8 to 17 degrees and increase the risk of cardiovascular disease. A health statement approved by the US FDA stated that as part of a diet low in saturated fat and cholesterol, consuming 1.3 grams of plant sterols per day can reduce the risk of heart disease. (For plant stannane, the daily dose can be increased to 3.4 grams) This new research has developed an alternative, encapsulating microencapsulated apple extract in maltodextrin.
Studies have shown that apple polyphenol extract can reduce the solubility and absorption of cholesterol in the intestine, and can be used as a natural solution for cholesterol control and cardiovascular health support. The researchers pointed out that the polar microencapsulated formula enables AMD to achieve micellar goals through a better carrier dimer proanthocyanidin. In addition, this product can be regarded as a powerful tool to reduce the solubility of duodenal cholesterol and reduce the bioavailability of the intestinal tract. This is the first report on the effect of apple polyphenol extract on the absorption of intestinal cholesterol, which opens up a new direction for the application of apple polyphenol extract.
