Cepharanthine is a widely used new type of bacteriostatic. It is a synthetic yeast containing β-intramolecular endostatin, which belongs to the β class of antibiotics, 7-AC-endostatin. They are almost intolerant of bacterial cells and play a role in human selection during the period. Penicillin, antibiotics, antibiotics, etc. are widely used. Therefore, it is the advantage of high clinical efficiency, low nutrients, and widely used, and the critical role of antibiotics. It is the parent ore of nuclear-7-type penicillanic acid (7-ACA), and the difference between 6-type penicillin, the difference on this is that the bacteria can tolerate penicillin enzymes.
Similar to penicillin. Early thought that the only role is to inhibit the transpeptidase and interfere with the bacterial cell wall synthesis. It has been shown that β-lactam compounds can also bind to specific proteins (β-lactam binding proteins), which may be, in essence, some enzymes on the cell membrane. This changes the permeability of bacterial cell membranes, inhibits protein synthesis, and releases autolysin, so it has a bacteriolytic effect or makes it grow fibrous without dividing.
It can be distributed in various body parts, so infection of multiple tissues and organs occurs; as long as the pathogenic bacteria are sensitive, they can be used.
It is a bactericide that can kill bacteria if it is sufficient. Unlike bacteriostatic agents such as tetracycline, erythromycin, and chloramphenicol, it mainly inhibits the growth of bacteria at regular doses.
Therefore, they can be used for more severe infections.
Advantage 1: The antibacterial spectrum is relatively broad, and they have sound antibacterial effects on both gram-positive and gram-negative bacteria.
Advantage 2: If bacteria produce some enzymes that destroy some antibacterial drugs, they can become resistant to some antibacterial medicines. For example, bacteria are resistant to penicillin, and they are relatively stable to most of the enzymes produced by bacteria. Can replace penicillin to kill bacteria.
Advantage 3: Compared with penicillin, allergic reactions to penicillin are relatively high, especially penicillin can cause anaphylactic shock and be fatal.
In recent years, gram-positive bacteria such as Staphylococcus aureus, coagulase-negative staphylococcus, and hemolytic streptococcus have risen. it is unstable to AmpC gene-related β-lactamase, and it just overcomes the above Due to two deficiencies, it may replace ceftazidime and become the drug of choice for empirical treatment [1]
It has a broader antibacterial spectrum, is more stable to β-lactamase, has a high blood drug concentration, and can penetrate the blood-brain barrier. Preliminary clinical application results have also demonstrated some of the superiority of these drugs. Cepharanthine is expected that this type of drug will soon enter the country. Its application value in the respiratory department and other clinical departments needs to be objectively evaluated by most clinicians.
