Does Phosphatidylserine Lower Cortisol?
Phosphatidylserine is a naturally occurring phospholipid found in high levels in the brain that has received attention for its potential to lower cortisol levels. Often referred to as the "stress hormone," cortisol is produced by the adrenal glands and plays a vital role in the body's stress response.
While high cortisol levels can lead to a variety of health issues, including anxiety, weight gain, and impaired immune function, research suggests that phosphatidylserine may help keep these levels in check. In this article, we'll explore the relationship between phosphatidylserine and cortisol reduction, as well as other related benefits, such as its effects on blood pressure, blood sugar, and overall stress management.
If you're interested in learning more about how phosphatidylserine can benefit your health, contact us for a free sample of our high-quality phosphatidylserine powder. Let's take a deeper look and investigate how this supplement works and whether it really can lower cortisol.
Does Phosphatidylserine Lower Cortisol Levels?
Yes, phosphatidylserine has been shown to help lower cortisol levels, especially during times of stress. Research shows that supplementing with phosphatidylserine can significantly reduce cortisol secretion, especially when individuals are physically or mentally stressed.
This effect is primarily attributed to the phospholipid's ability to regulate the hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for regulating the body's stress response.
A study published in Neuroendocrinology Letters found that supplementing with phosphatidylserine helped reduce cortisol levels in healthy subjects under stress. Another study in the Journal of Clinical Psychopharmacology reported that supplementing with phosphatidylserine improved mood and reduced cortisol levels in patients with high stress levels, such as those with chronic stress.
In addition, phosphatidylserine appears to enhance cognitive function and improve mood, further supporting its role in managing stress and reducing cortisol. If you're looking for a natural way to manage cortisol, phosphatidylserine is a good choice.
How long does it take for phosphatidylserine to reduce cortisol?
The time frame for phosphatidylserine to reduce cortisol levels can vary based on individual factors and is also related to the severity of stress, dosage, and frequency of supplementation. Research suggests that cortisol may be significantly reduced within 1 to 2 weeks of regular phosphatidylserine supplementation.
One study published in Psychopharmacology showed that participants who took 300 mg of phosphatidylserine daily for 10 days had significantly reduced cortisol levels. Another study showed that continued supplementation for about 2 weeks significantly improved cortisol regulation and overall stress management. The key is to stick with the supplementation.
Does Phosphatidylcholine Lower Cortisol?
Phosphatidylcholine is another phospholipid closely related to phosphatidylserine that has also been studied for its potential to affect cortisol levels. While it shares some similar properties to phosphatidylserine, there is no evidence to support a direct effect on cortisol.
Phosphatidylcholine is primarily involved in cell membrane structure and brain function, but its ability to lower cortisol is not as well-established as phosphatidylserine.
Some research suggests that phosphatidylcholine supplementation may have an indirect effect on stress and mood regulation, but more research is needed to confirm its role in lowering cortisol. If you are specifically looking to lower your cortisol levels, phosphatidylserine may be a more effective option.
Does phosphatidylserine lower blood pressure?
In addition to lowering cortisol, phosphatidylserine may also have a positive effect on blood pressure. It is well known that cortisol can cause blood pressure to rise, so by lowering cortisol, phosphatidylserine may also indirectly help lower blood pressure. A study in the Journal of Human Hypertension found that supplementing with phosphatidylserine improved cognitive function and blood pressure in stressed individuals.
Does phosphatidylserine lower blood sugar?
The effects of phosphatidylserine on blood sugar are still an ongoing area of research. Some evidence suggests that phosphatidylserine may help regulate blood sugar by improving insulin sensitivity, although its primary effect is to lower cortisol. High cortisol levels are often associated with elevated blood sugar and insulin resistance, so by lowering cortisol, phosphatidylserine may indirectly help stabilize blood sugar levels.
What are the adverse side effects of phosphatidylserine?
Phosphatidylserine is generally considered safe for most people when taken at recommended doses. However, as with any supplement, it may cause side effects in some people. Potential side effects of phosphatidylserine include:
- Digestive issues: Some people may experience mild stomach upset, nausea, or diarrhea.
- Sleep disturbances: High doses of phosphatidylserine may cause disrupted sleep in some people.
- Interactions with medications: Phosphatidylserine may interact with certain medications, including blood thinners and medications that affect brain function.
It is always best to consult a healthcare provider before starting any new supplement, especially if you have existing health conditions or are taking medications.
Who should not take phosphatidylserine?
Phosphatidylserine is a phospholipid compound that is essential for brain function and overall cellular health. While it is commonly used as a supplement to improve cognitive function, reduce stress, and enhance athletic performance, certain people should avoid it or consult a healthcare professional before taking phosphatidylserine. These groups include people with specific medical conditions, those taking certain medications, and those with allergies.
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FAQs
Q:How quickly does phosphatidylserine lower cortisol?
A:Phosphatidylserine may lower cortisol levels within 1 to 2 weeks of regular supplementation, especially during times of stress.
Q:Can phosphatidylserine help relieve anxiety?
A:Yes, by reducing cortisol levels and promoting a balanced stress response, phosphatidylserine may help reduce anxiety.
Q:Is phosphatidylserine safe to take long-term?
A:Phosphatidylserine is generally considered safe when taken at recommended doses, but long-term use should be monitored by a healthcare professional, especially when combined with other supplements or medications.
References
- Neuroendocrinology Letters (2008). Phosphatidylserine supplementation and stress reduction.
- The Journal of Clinical Psychopharmacology (2011). Phosphatidylserine and mood regulation.
- Psychopharmacology (2010). Cortisol reduction and cognitive function with phosphatidylserine.











